Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Csgalnact1-/- mice by using a targeting vector for Csgalnact1 gene disruption | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | Mus musculus | - |
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan | - |
? | |
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | Mus musculus C57/BL6J | - |
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57/BL6J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | quantitative analysis of Csgalnact1 and Csgalnact2 transcripts in brain of wild-type and Csgalnact1-/- mice by real-time PCR, overview | Mus musculus | - |
cartilage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | - |
Mus musculus | UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan | - |
? | |
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan | - |
Mus musculus C57/BL6J | UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan | - |
? |
Synonyms | Comment | Organism |
---|---|---|
chondroitin sulfate N-acetylgalactosaminyltransferase 1 | - |
Mus musculus |
CSGalNAcT-1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | the growth plate of Csgalnact1-/- mice contains shorter and slightly disorganized chondrocyte columns with a reduced volume of the extracellular matrix principally in the proliferative layer. Immunohistochemical analysis reveals that the level of both aggrecan and link protein 1 are decreased in Csgalnact1-/- cartilage with an increase in processed forms of aggrecan core protein, phenotype, overview | Mus musculus |
metabolism | chondroitin sulfate biosynthetic pathway and relevant glycosyltransferases, overview | Mus musculus |
physiological function | chondroitin sulfate N-acetylgalactosaminyltransferase 1, CSGalNAcT-1, participates in the chondroitin sulfate chain initiation and is necessary for normal endochondral ossification and aggrecan metabolism | Mus musculus |